Hyaluronic acid-b-polylactic acid polymersomes facilitate CD44-mediated delivery of doxorubicin to glioblastoma in vitro
Apoorvi Chaudhri, Molli Garifo, Pranavi Thatavarthi, Torrick Fletcher, Jessica Larsen · 2026
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Description
Apoorvi Chaudhri and colleagues package a chemotherapy drug in tiny polymer bubbles for brain tumours. Their in vitro study from twenty twenty-six targets glioblastoma cells. Doxorubicin kills tumour cells but cannot cross into the brain. A carrier is needed to smuggle it past that barrier.
The bubbles combine hyaluronic acid with a biodegradable plastic. Hyaluronic acid homes to a receptor common on tumour cells. That receptor guides the drug package into the cancer cells. The standard brain tumour drug buys patients only months. This drug works through a route that bypasses common resistance. Lab results support further testing toward animal studies.
Catalog record
| CREATOR | Apoorvi Chaudhri, Molli Garifo, Pranavi Thatavarthi, Torrick Fletcher, Jessica Larsen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |