Associations between maternal adiposity during pregnancy and neonatal brain cortical development
Xiaoxu Na, Brooke L Yancey-Ward, Yan Xue, Charles M Glasier, Yongming Liu, Xiawei Ou · 2026
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Description
Xiaoxu Na and colleagues test whether a mother's body fat during pregnancy relates to her newborn's brain cortex development. Their 2026 prospective study follows 169 mother and newborn pairs, measuring maternal fat directly rather than relying on body mass index.
Fat mass percentage was measured at 12 and 36 weeks of pregnancy using air displacement, a method that estimates body composition from displaced air. At about two weeks old, babies had brain scans during natural sleep. Higher maternal fat at both time points was linked to smaller cortical volume in memory-related regions, including the left entorhinal cortex and parahippocampal gyrus. Late-pregnancy fat was also linked to the right temporal pole. One region showed a sex-specific effect, suggesting boys and girls may be affected differently.
Catalog record
| CREATOR | Xiaoxu Na, Brooke L Yancey-Ward, Yan Xue, Charles M Glasier, Yongming Liu, Xiawei Ou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |