Beyond histocompatibility: human leukocyte antigen as a cross-disciplinary platform for immune recognition and clinical decision-making
Saikat Mandal, Joyisa Deb, Aswin K. Mohan, Suhasini Sil, Manideepa Maji, Shirin Hasan, Fahad Hassan Ashraf, Arkadeep Dhali · 2026
Read Beyond histocompatibility: human leukocyte antigen as a cross-disciplinary platform for immune recognition and clinical decision-making by Saikat Mandal, Joyisa Deb, Aswin K. Mohan, Suhasini Sil, Manideepa Maji, Shirin Hasan, Fahad Hassan Ashraf, Arkadeep Dhali (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13595195.txt.
Description
The HLA genes decide whose organs match whose, but the authors of this review argue their reach runs far wider. These molecules present protein fragments to the immune system, and their variation shapes transfusion reactions, autoimmune disease, drug safety, cancer escape, pregnancy, and both kinds of transplant. The review walks through modern testing, from sequence-based typing to bead assays and computer crossmatching. It warns that a result means little without context: drug exposures, antibody strength, ancestry, and the organ involved all bend its meaning.
Practical payoffs already exist, such as screening before prescribing certain drugs known to trigger HLA-linked reactions. The authors close by separating settled practice from promising scores still earning their place, and by demanding validation across ancestries.
Catalog record
| CREATOR | Saikat Mandal, Joyisa Deb, Aswin K. Mohan, Suhasini Sil, Manideepa Maji, Shirin Hasan, Fahad Hassan Ashraf, Arkadeep Dhali |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |