Oncolytic bacteria therapy for malignant glioma
Feiyue Li, Jing Zhao, Ang Ji, Junlong Zhao, Sanzhong Li · 2026
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Description
Feiyue Li and co-authors wrote a review from 2026 on using live bacteria as a weapon against malignant glioma, the most aggressive family of brain tumors. These cancers invade widely, vary cell to cell, and hide behind the blood-brain barrier, so surgery, radiation, and chemotherapy all fall short. Their oxygen-starved cores, usually a source of resistance, offer a target instead. Certain bacteria thrive exactly where oxygen is absent.
Such bacteria home to the tumor's deep, low-oxygen zones and multiply there. They can burst tumor cells directly and wake the local immune system. They also sidestep the barrier that blocks most drugs. The review covers the main strains, their killing mechanisms, and how gene editing and synthetic biology are tuning them. It then sums up animal results and early human trials. Biosafety, delivery, and measuring benefit remain the hard problems for the clinic, the authors conclude.
Catalog record
| CREATOR | Feiyue Li, Jing Zhao, Ang Ji, Junlong Zhao, Sanzhong Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 102 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |