Downregulation of prenylation machinery genes in peripheral blood of patients with Parkinson’s disease: A pilot study
Mohammad Jalal Tabatabaie, Solat Eslami, Atefe Abak, Soudeh Ghafouri-Fard · 2026
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Description
Mohammad Jalal Tabatabaie and co-authors report a 2026 pilot study on gene activity in the blood of Parkinson's patients. Parkinson's is a brain disease with many contributing factors. Blood based markers could reveal its molecular shifts. The team focused on genes for a process called prenylation, which tags proteins so they can guide transport inside cells. They measured five such genes in blood from patients and healthy controls.
Four of the five genes ran clearly lower in patients. The fifth dipped only slightly. Single gene tests sorted patients from controls well to excellently. A combined model using the four strong genes reached near top accuracy. The genes also rose and fell together, which hints at a pathway level disturbance. The authors caution that drug effects and blood cell mix could not be fully ruled out, so outside validation is still needed.
Catalog record
| CREATOR | Mohammad Jalal Tabatabaie, Solat Eslami, Atefe Abak, Soudeh Ghafouri-Fard |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |