Elucidating shared genetic signals between type 2 diabetes and three neurodegenerative dementia phenotypes
Ana Luiza Arruda, Archit Singh, Ozvan Bocher, Benjamin F. Voight, Andrew P. Morris, Eleftheria Zeggini · 2026
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Description
Ana Luiza Arruda and co-authors hunt for gene signals shared between type two diabetes and three dementia forms, in work from twenty twenty-six. Diabetes and dementia co-occur often, but the shared biology stays murky. Large gene studies of diagnosed cases anchor the search. Three dementia forms are tested: Alzheimer, Lewy body, and frontotemporal types. Multi-layer tissue data help pin which genes carry the shared signals.
Five genome regions hold signals shared with at least one dementia form. The APOE region is shared across all three dementia forms. The other four regions each pair diabetes with a single form. Two dozen candidate genes are prioritised through the layered evidence. Fat and lipoprotein control paths stand out as a shared axis. Gene-driven tests suggest one signal can push the two diseases apart. The map frames how metabolic and brain ageing trade off.
Catalog record
| CREATOR | Ana Luiza Arruda, Archit Singh, Ozvan Bocher, Benjamin F. Voight, Andrew P. Morris, Eleftheria Zeggini |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |