ABCB1 genotype and clinically relevant bleeding risk during extended anticoagulation therapy for pulmonary embolism: a two-phase study
Zhu Zhang, Haobo Li, Bingzhang Zou, Xiaofan Ji, Yu Zhang, Yuzhi Tao, Linfeng Xi, Kuangxun Li, Huiwen Li, Mengjie Duo, Li Zhao, Xianbo Zuo, Zhenguo Zhai, Chen Wang, CURES investigators · 2026
Read ABCB1 genotype and clinically relevant bleeding risk during extended anticoagulation therapy for pulmonary embolism: a two-phase study by Zhu Zhang, Haobo Li, Bingzhang Zou, Xiaofan Ji, Yu Zhang, Yuzhi Tao, Linfeng Xi, Kuangxun Li, Huiwen Li, Mengjie Duo, Li Zhao, Xianbo Zuo, Zhenguo Zhai, Chen Wang, CURES investigators (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13594809.txt.
Description
Zhu Zhang and co-authors hunt in 2026 for gene traits that raise bleeding risk in lung clot patients on long blood-thinner care. Long use of the drugs cuts repeat clots, yet bleeding stays a real danger. How much drug reaches the blood varies a lot by person, and the gene side of that gap was unclear.
Phase one held 633 patients on one thinner, with gene data from a multi-center registry. Thirteen candidate gene variants, across nine genes tied to drug handling, were tested against bleeding. Phase two checked drug levels and genes in 101 more patients. Work like this could one day let doctors set dose by gene, rather than learn a patient's bleeding risk the hard way.
Catalog record
| CREATOR | Zhu Zhang, Haobo Li, Bingzhang Zou, Xiaofan Ji, Yu Zhang, Yuzhi Tao, Linfeng Xi, Kuangxun Li, Huiwen Li, Mengjie Duo, Li Zhao, Xianbo Zuo, Zhenguo Zhai, Chen Wang, CURES investigators |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |