Transcriptomic characterization of transitional B cells reveals four subsets with perturbed activation profiles in scleroderma
Claire Beesley, Nina Goldman, Gisela Gabernet, Edel Aron, Cankut Çubuk, Myles J Lewis, Louisa K James, Gur Yaari, Steven H Kleinstein, David J Abraham, Christopher P Denton, Rizgar A Mageed, Voon Ong · 2026
Read Transcriptomic characterization of transitional B cells reveals four subsets with perturbed activation profiles in scleroderma by Claire Beesley, Nina Goldman, Gisela Gabernet, Edel Aron, Cankut Çubuk, Myles J Lewis, Louisa K James, Gur Yaari, Steven H Kleinstein, David J Abraham, Christopher P Denton, Rizgar A Mageed, Voon Ong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13594708.txt.
Description
Claire Beesley and twelve co-authors published an immunology study in twenty twenty-six profiling immature B cells in scleroderma, the autoimmune disease that hardens skin and organs. The team had earlier found these transitional B cells wrongly surviving with self-reactive receptors, hinting at a broken tolerance checkpoint. Single-cell sequencing now dissects them.
Four subsets appeared, and the earliest, T1, was doubled in patients versus healthy controls. Patient cells switched on survival and interferon-response genes and carried antibody regions with altered chemistry. A signaling pathway driven by AKT likely keeps the rogue cells alive. The portrait nominates that pathway as a drug target for restoring immune tolerance.
Catalog record
| CREATOR | Claire Beesley, Nina Goldman, Gisela Gabernet, Edel Aron, Cankut Çubuk, Myles J Lewis, Louisa K James, Gur Yaari, Steven H Kleinstein, David J Abraham, Christopher P Denton, Rizgar A Mageed, Voon Ong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |