Robotic handling preserves iPSC-derived vascular smooth muscle cell differentiation
Monique Bax, Jeya Ramalingam, Valentin Romanov, Muhammad A Alsherbiny, Keerat Junday, Jordan Thorpe, Emily Hurley, Melanie Lim, Ingrid Tarr, Stephanie Hesselson, Eleni Giannoulatou, Renjing Liu, Adam Hill, Siiri Iismaa, Robert M Graham · 2026
Read Robotic handling preserves iPSC-derived vascular smooth muscle cell differentiation by Monique Bax, Jeya Ramalingam, Valentin Romanov, Muhammad A Alsherbiny, Keerat Junday, Jordan Thorpe, Emily Hurley, Melanie Lim, Ingrid Tarr, Stephanie Hesselson, Eleni Giannoulatou, Renjing Liu, Adam Hill, Siiri Iismaa, Robert M Graham (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13594703.txt.
Description
Bax and co-authors show that robots can raise vessel wall cells from stem cells without spoiling them, in this 2026 paper. Growing vascular smooth muscle cells at scale is a bottleneck for studying heart disease. Automation promises volume and consistency, but nobody had checked whether machine handling harms the delicate differentiation.
Their protocol works by hand or on a liquid-handling robot, starting from stem cells of donors of both sexes and varied ages. The grown cells matched primary vessel cells in shape and marker proteins, and they contracted when given a vessel-tightening drug. Protein profiles from robot-grown and hand-grown batches were nearly identical. Output rose while manual labor fell. The team calls it a step toward factory-scale cell manufacture.
Catalog record
| CREATOR | Monique Bax, Jeya Ramalingam, Valentin Romanov, Muhammad A Alsherbiny, Keerat Junday, Jordan Thorpe, Emily Hurley, Melanie Lim, Ingrid Tarr, Stephanie Hesselson, Eleni Giannoulatou, Renjing Liu, Adam Hill, Siiri Iismaa, Robert M Graham |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |