Equipotent Doses and ED95 Extrapolation: Methodological Concerns in Trials of Ciprofol-Esketamine/Sufentanil for Elderly ESD [Letter]
Luoyun Li, Zeru Zhang, Zehua Wang, Chunyu Li · 2026
Read Equipotent Doses and ED95 Extrapolation: Methodological Concerns in Trials of Ciprofol-Esketamine/Sufentanil for Elderly ESD [Letter] by Luoyun Li, Zeru Zhang, Zehua Wang, Chunyu Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13594508.txt.
Description
Luoyun Li and three co-authors write a letter that questions dose choices in a sedation trial for older adults. The trial mixed a new sedative with one of two pain drugs for gut surgery. Both pain doses sit in normal range, but past work hints they are not matched in strength.
The stronger arm also lifts blood pressure on its own, while the other can slow breath, so gaps in faintness or low oxygen may stem from dose, not the new drug. Lack of masking and two main outcomes add more doubt. Careful reading is urged before the results guide care.
Catalog record
| CREATOR | Luoyun Li, Zeru Zhang, Zehua Wang, Chunyu Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |