Benzothiazepane‐Based Curcumin Analogs Show Selective Effects on Respiration, Permeability, and Growth of Gut‐Liver (Co‐Culture) Cell Models
Fuhua Li, Julie De Munck, Felien Morlion, Katarina Magdalenic, Andreja Rajkovic, Matthias D'hooghe, John Van Camp, Charlotte Grootaert · 2026
Read Benzothiazepane‐Based Curcumin Analogs Show Selective Effects on Respiration, Permeability, and Growth of Gut‐Liver (Co‐Culture) Cell Models by Fuhua Li, Julie De Munck, Felien Morlion, Katarina Magdalenic, Andreja Rajkovic, Matthias D'hooghe, John Van Camp, Charlotte Grootaert (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13594503.txt.
Description
Fuhua Li and seven co-authors test four lab-made cousins of curcumin in gut and liver cells, in a 2026 paper. Curcumin, the yellow spice compound, can fight cancer cells but breaks down fast and harms cells without aim. The four cousins carry a new ring core with small side groups swapped in and out. The team asked how each cousin treats colon and liver cell lines, grown apart and together.
Small swaps in the side groups changed the harm a lot. Two cousins hit colon cells a bit softer than curcumin, one did nothing, and one matched it. Liver cells took less harm than colon cells when dosed alone. Yet when the two cell types grew together, the gut cells' output made a dose deadly to liver cells. One cousin also wrecked the colon cells' power plants most strongly.
Catalog record
| CREATOR | Fuhua Li, Julie De Munck, Felien Morlion, Katarina Magdalenic, Andreja Rajkovic, Matthias D'hooghe, John Van Camp, Charlotte Grootaert |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |