Individualized dose–response algorithm vs weight-based heparin dosing for intraprocedural anticoagulation during atrial fibrillation ablation
Jared Bryce Pleash, Jonathan O’Leary, Michael David Fryer, Tuppence Richman, Philip Cumpston, Matthew K.Y. Tung · 2026
Read Individualized dose–response algorithm vs weight-based heparin dosing for intraprocedural anticoagulation during atrial fibrillation ablation by Jared Bryce Pleash, Jonathan O’Leary, Michael David Fryer, Tuppence Richman, Philip Cumpston, Matthew K.Y. Tung (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13594459.txt.
Description
Jared Pleash and colleagues compared a personalised heparin dosing algorithm with standard weight-based dosing during atrial fibrillation ablation. Steady blood thinning during ablation matters, since too little risks clots and too much risks bleeding. Their look-back study covered 238 ablations at one centre, 125 weight-based and 113 algorithm-guided, aiming for a clotting time of 350 seconds.
Algorithm dosing hit the target more often at every time point and cut variability sharply early on, with spread at 40 minutes of about 14 seconds versus about 43 seconds. Gains were largest in patients under 80 kilograms, where deviation fell by about 27 seconds at 10 minutes. The authors call for prospective trials to test whether steadier thinning improves patient outcomes.
Catalog record
| CREATOR | Jared Bryce Pleash, Jonathan O’Leary, Michael David Fryer, Tuppence Richman, Philip Cumpston, Matthew K.Y. Tung |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |