Reduced Pathogen‐Specific T Cell Response With BCMA‐Targeted T Cell‐Engaging Therapy to Multiple Myeloma
Ida Steiro, Synne Stokke Tryggestad, Eli Svorkdal Hess, Hanne Hella, Pegah Abdollahi, Kari Lenita Falck Moore, Margrete Friestad, Magne Børset, Tobias S Slørdahl, Anne Marit Sponaas · 2026
Read Reduced Pathogen‐Specific T Cell Response With BCMA‐Targeted T Cell‐Engaging Therapy to Multiple Myeloma by Ida Steiro, Synne Stokke Tryggestad, Eli Svorkdal Hess, Hanne Hella, Pegah Abdollahi, Kari Lenita Falck Moore, Margrete Friestad, Magne Børset, Tobias S Slørdahl, Anne Marit Sponaas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13594405.txt.
Description
Ida Steiro leads a ten-author team asking whether bispecific antibody therapy for multiple myeloma weakens the T cells' memory of past infections, helping explain why treated patients suffer more infections. The therapy joins T cells to a target called BCMA on myeloma cells. The team tested T cells from healthy donors. The cells were grown with the engager drug pavurutamab and with myeloma cells.
Those T cells still killed myeloma cells well, yet their responses to common pathogen fragments dropped compared with untreated cells. A small exploratory check of blood from four patients responding to the same class of therapy pointed the same way, with reduced pathogen-specific memory responses. The authors are careful to call the observation preliminary, urging a larger study to confirm whether this immune dulling truly drives the infection burden.
Catalog record
| CREATOR | Ida Steiro, Synne Stokke Tryggestad, Eli Svorkdal Hess, Hanne Hella, Pegah Abdollahi, Kari Lenita Falck Moore, Margrete Friestad, Magne Børset, Tobias S Slørdahl, Anne Marit Sponaas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |