Functional and morphological alterations of light detection circuits in postmortem retina from donors with different stages of Alzheimer’s-like pathology
Nicolae Sanda, Dan Milea, Eniko Kovari, Yixin Tong, Arianna Cella, Talayeh Brügger, Jens Hannibal, Kristof Levente Egervari, Johannes Alexander Lobrinus, Emmanuel Carrera, Gabriele Thumann, Sonja Kleinlogel, Antoine Adamantidis, Ludovic S. Mure · 2026
Read Functional and morphological alterations of light detection circuits in postmortem retina from donors with different stages of Alzheimer’s-like pathology by Nicolae Sanda, Dan Milea, Eniko Kovari, Yixin Tong, Arianna Cella, Talayeh Brügger, Jens Hannibal, Kristof Levente Egervari, Johannes Alexander Lobrinus, Emmanuel Carrera, Gabriele Thumann, Sonja Kleinlogel, Antoine Adamantidis, Ludovic S. Mure (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13594353.txt.
Description
Nicolae Sanda and a team of co-authors examined the retinas of thirteen elderly donors. The donors spanned normal cognition to Alzheimer's disease. The team focused on the special ganglion cells that sense light for the body clock rather than for vision. Sleep and rhythm problems are among the earliest Alzheimer's complaints, and these cells drive them, so the team recorded electrical responses from freshly harvested retinas.
Ordinary light-sensing rods and cones worked normally, but the clock-related cells were severely depleted in Alzheimer's donors. Survivors looked structurally altered, fired too easily, and could not sustain strong activation. The pattern varied between donors, possibly by cell subtype and disease stage. The authors propose that measuring these cells' light responses might one day help flag or track Alzheimer's changes in the brain, while their failure helps explain the disease's rhythm disruption.
Catalog record
| CREATOR | Nicolae Sanda, Dan Milea, Eniko Kovari, Yixin Tong, Arianna Cella, Talayeh Brügger, Jens Hannibal, Kristof Levente Egervari, Johannes Alexander Lobrinus, Emmanuel Carrera, Gabriele Thumann, Sonja Kleinlogel, Antoine Adamantidis, Ludovic S. Mure |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51552 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |