Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations
Sarah A Berger, Christopher Grimm, Marco Cespugli, Andreas Krassnigg, Tobias Schopper, Irene Marzuoli, Isabel Oroz-Guinea, Stephan Vrabl, Lukas Roemer, Melanie A Weber, Fabian M Kulier, Yuliya Orel, Bettina M Nestl, Christian C Gruber, Georg Steinkellner, Serena Bisagni, Francis Gosselin, Hans Iding · 2026
Read Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations by Sarah A Berger, Christopher Grimm, Marco Cespugli, Andreas Krassnigg, Tobias Schopper, Irene Marzuoli, Isabel Oroz-Guinea, Stephan Vrabl, Lukas Roemer, Melanie A Weber, Fabian M Kulier, Yuliya Orel, Bettina M Nestl, Christian C Gruber, Georg Steinkellner, Serena Bisagni, Francis Gosselin, Hans Iding (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13594329.txt.
Description
Sarah Berger and co-authors build a library of enzymes that join amines with high precision. Imine reductases and reductive aminases make chiral amines, prized building blocks for drugs, but how wide their reach runs was murky. Their 2026 study screens activity across one hundred seventy-five enzymes and diverse substrate pairs, in rounds guided by data.
Machine learning steered which enzymes to test next, and sequence analysis flagged what the broad-scope ones share. High-yield joining at equal amounts of both starting materials turned out to be common in the family. The final library pairs broad reach with strong activity and clean stereoselectivity. Biocatalysis teams get a vetted enzyme shelf plus the sequence signs that predict a versatile catalyst.
Catalog record
| CREATOR | Sarah A Berger, Christopher Grimm, Marco Cespugli, Andreas Krassnigg, Tobias Schopper, Irene Marzuoli, Isabel Oroz-Guinea, Stephan Vrabl, Lukas Roemer, Melanie A Weber, Fabian M Kulier, Yuliya Orel, Bettina M Nestl, Christian C Gruber, Georg Steinkellner, Serena Bisagni, Francis Gosselin, Hans Iding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |