Single-cell transcriptomics reveals differences between chorionic and basal plate cytotrophoblasts and 2D-cultured trophoblast stem cells
Robert Morey, Francesca Soncin, Sampada Kallol, Nirvay Sah, Zoe Manalo, Tony Anh Bui, Jaroslav Slamecka, Virginia Chu Cheung, Donald Pizzo, Daniela F. Requena, Ching-Wen Chang, Omar Farah, Ryan Kittle, Kelly Lam, Morgan Meads, Mariko Horii, Kathleen M. Fisch, Mana M. Parast · 2026
Read Single-cell transcriptomics reveals differences between chorionic and basal plate cytotrophoblasts and 2D-cultured trophoblast stem cells by Robert Morey, Francesca Soncin, Sampada Kallol, Nirvay Sah, Zoe Manalo, Tony Anh Bui, Jaroslav Slamecka, Virginia Chu Cheung, Donald Pizzo, Daniela F. Requena, Ching-Wen Chang, Omar Farah, Ryan Kittle, Kelly Lam, Morgan Meads, Mariko Horii, Kathleen M. Fisch, Mana M. Parast (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13594312.txt.
Description
Robert Morey leads an eighteen-author team mapping the diversity of cytotrophoblasts, the progenitor cells of the early placenta, at single-cell resolution. Their 2026 study sequenced cells from placental tissue at six to eight weeks and at twelve to fourteen weeks of pregnancy. They compared the fetal-side and maternal-side regions. The results were set against lab-grown trophoblast stem cells.
Location shaped identity: progenitors clustered near the maternal plate and leaned toward becoming invasive cells, while fetal-side cells leaned toward the fused surface layer that exchanges nutrients. Stem cell lines grown in dishes most resembled precursors of the invasive type, and they lost the marker genes of the true starting state as they adapted to culture. The findings matter for anyone using these stem cells to model pregnancy, since the dish-grown version represents only part of the original population.
Catalog record
| CREATOR | Robert Morey, Francesca Soncin, Sampada Kallol, Nirvay Sah, Zoe Manalo, Tony Anh Bui, Jaroslav Slamecka, Virginia Chu Cheung, Donald Pizzo, Daniela F. Requena, Ching-Wen Chang, Omar Farah, Ryan Kittle, Kelly Lam, Morgan Meads, Mariko Horii, Kathleen M. Fisch, Mana M. Parast |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89844 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |