Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity
Manuel Gil-Lozano, Estefanía Simoes, Moya Wu, Tobias Wiedemann, Yun Kwon, Revathi Sekar, Pauline Morigny, Maria Troullinaki, Juliane Merl-Pham, Michael Buettner, Annette Feuchtinger, Celine Jouffe · 2026
Read Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity by Manuel Gil-Lozano, Estefanía Simoes, Moya Wu, Tobias Wiedemann, Yun Kwon, Revathi Sekar, Pauline Morigny, Maria Troullinaki, Juliane Merl-Pham, Michael Buettner, Annette Feuchtinger, Celine Jouffe (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13594115.txt.
Description
Manuel Gil-Lozano and a large team show that silencing a cluster of small regulatory RNAs in the liver can reset blood sugar and fat balance in mice. The cluster, called miR-379/miR-410, sits in a gene region known for shaping metabolic tissues early in life, and its members climb sharply in the livers of obese humans and mice.
The team expressed a decoy molecule only in liver cells of adult mice, soaking up the whole cluster at once. Treated animals showed lower triglycerides and LDL cholesterol, lower resting blood sugar, and better glucose tolerance and insulin sensitivity in both sexes. Liver cells gained more and healthier mitochondria alongside stronger insulin signaling. The approach also improved metabolism in male mice modeling type 1 diabetes and diet-driven pre-diabetes, suggesting a cluster-wide target for metabolic disease.
Catalog record
| CREATOR | Manuel Gil-Lozano, Estefanía Simoes, Moya Wu, Tobias Wiedemann, Yun Kwon, Revathi Sekar, Pauline Morigny, Maria Troullinaki, Juliane Merl-Pham, Michael Buettner, Annette Feuchtinger, Celine Jouffe |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |