Integrative single-cell and bulk transcriptomics define polyamine-associated cell states in acute myeloid leukemia and implicate CCT6A in polyamine homeostasis
Aimei Feng, Xiaohe Chen, Fan Chen, Xiaowu Wang, Mengjia Peng, Jue Zeng, Ming Chen · 2026
Read Integrative single-cell and bulk transcriptomics define polyamine-associated cell states in acute myeloid leukemia and implicate CCT6A in polyamine homeostasis by Aimei Feng, Xiaohe Chen, Fan Chen, Xiaowu Wang, Mengjia Peng, Jue Zeng, Ming Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13593858.txt.
Description
Aimei Feng and co-authors map polyamine states in acute myeloid leukemia in a 2026 study. Polyamines feed cell growth, and leukemias lean on that feed, yet how the lean spreads across cell kinds was unclear. The team joined single cell reads from 41 cases with bulk profiles from 712 patients.
A 76 gene score showed polyamine action richest in blast cells, tied to stem like traits, fast growth, and weak maturing. Two subtypes split by metabolic and immune marks. A survival model sorted patients by risk with fair strength. One gene, CCT6A, ran high and held the polyamine pool in check in lab tests.
Catalog record
| CREATOR | Aimei Feng, Xiaohe Chen, Fan Chen, Xiaowu Wang, Mengjia Peng, Jue Zeng, Ming Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |