Cloning of a novel cyanobacterial serotonin N-acetyltransferase gene CySNAT3 and its integration with transcriptomic drug repurposing in pediatric obstructive sleep-disordered breathing
Wen Wen, Fei Xu, Yaoming Xu, Yifei Gao, Honglin Song, Yang Lv, Peng Yan · 2026
Read Cloning of a novel cyanobacterial serotonin N-acetyltransferase gene CySNAT3 and its integration with transcriptomic drug repurposing in pediatric obstructive sleep-disordered breathing by Wen Wen, Fei Xu, Yaoming Xu, Yifei Gao, Honglin Song, Yang Lv, Peng Yan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13593818.txt.
Description
Wen and six colleagues clone a gene from blue green algae that helps make melatonin, and hunt drug leads for child sleep apnea in twenty twenty-six. Melatonin may aid children whose sleep breathing is blocked, often by swollen tonsils. Plant melatonin is slow and costly to extract. The algae gene, when placed in lab bacteria, made an enzyme that works two steps of the melatonin path.
In parallel, the team mined tonsil gene data for drug matches. Four known drugs stood out as leads. Computer docking showed each fits its target protein well. Two of the drugs have past links to the melatonin path. The two halves of the study meet in a plan for new care.
Catalog record
| CREATOR | Wen Wen, Fei Xu, Yaoming Xu, Yifei Gao, Honglin Song, Yang Lv, Peng Yan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |