Defining early carcinogenic markers for the prediction of the hazard potential of mineral fibres in an in vitro human 3D bronchial model
Vanessa Almonti, Serena Mirata, Mario Passalacqua, Stefania Vernazza, Sara Tirendi, Sara Ferrando, Beatrice Risso, Elena Grasselli, Giulia De Negri Atanasio, Anna Maria Bassi, Alessandro F Gualtieri, Sonia Scarfì · 2026
Read Defining early carcinogenic markers for the prediction of the hazard potential of mineral fibres in an in vitro human 3D bronchial model by Vanessa Almonti, Serena Mirata, Mario Passalacqua, Stefania Vernazza, Sara Tirendi, Sara Ferrando, Beatrice Risso, Elena Grasselli, Giulia De Negri Atanasio, Anna Maria Bassi, Alessandro F Gualtieri, Sonia Scarfì (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13593725.txt.
Description
Vanessa Almonti leads a twelve-author team hunting for early warning signs that mineral fibers can set lung tissue on the path to cancer. Their 2026 study exposed a three-dimensional human bronchial model, grown to mimic real airway tissue, to crocidolite asbestos and to short and long chrysotile fibers, then tracked the tissue's responses.
Tests in the first two days showed only brief toxicity that the tissue shook off, which would make a poor early test. By twelve days, though, fiber-treated tissue showed lasting changes matching known hallmarks of carcinogens. Inflammatory signals kept firing. DNA break markers persisted without much cell death. Scarring and identity-shifting programs had begun in the cells. The authors propose these signatures, combined with physical fiber measurements, as a faster way to judge the cancer risk of inhalable fibers.
Catalog record
| CREATOR | Vanessa Almonti, Serena Mirata, Mario Passalacqua, Stefania Vernazza, Sara Tirendi, Sara Ferrando, Beatrice Risso, Elena Grasselli, Giulia De Negri Atanasio, Anna Maria Bassi, Alessandro F Gualtieri, Sonia Scarfì |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68280 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |