NLRP3 inflammasome activation by particles and fibers: implications for human hazard assessment
Mathias Busch, Gerrit Bredeck, Hans Bouwmeester, Roel P. F. Schins · 2026
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Description
Mathias Busch, Gerrit Bredeck, Hans Bouwmeester, and Roel P. F. Schins review how inhaled or swallowed particles and fibers switch on the NLRP3 inflammasome, a protein assembly inside immune cells that drives inflammation. Their 2026 review gathers laboratory and animal work on materials from asbestos and quartz to microplastics and desert dust.
The chain from particle exposure through inflammasome activation to disease is firmly established for workplace mineral dusts. For the low-level environmental exposures people meet daily, that chain is still being traced. The authors argue that testing whether a new material activates NLRP3 should become a routine part of hazard assessment. The response appears across very different materials, and it sits upstream of lasting harm. Emerging materials such as nanocomposites could then be screened before wide use.
Catalog record
| CREATOR | Mathias Busch, Gerrit Bredeck, Hans Bouwmeester, Roel P. F. Schins |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74364 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |