Serum S100B and Clinical Outcomes After Spontaneous Subarachnoid Hemorrhage: A Prospective Observational Study
Anna Maria Auricchio, Silvia Baroni, Michele Nichelatti, Giulia Napoli, Francesco Calvanese, Giovanni Maria Ceccarelli, Renata Martinelli, Grazia Menna, Marco Obersnel, Luca Scarcia, Andrea Alexandre, Anselmo Caricato · 2026
Read Serum S100B and Clinical Outcomes After Spontaneous Subarachnoid Hemorrhage: A Prospective Observational Study by Anna Maria Auricchio, Silvia Baroni, Michele Nichelatti, Giulia Napoli, Francesco Calvanese, Giovanni Maria Ceccarelli, Renata Martinelli, Grazia Menna, Marco Obersnel, Luca Scarcia, Andrea Alexandre, Anselmo Caricato (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13593659.txt.
Description
Anna Maria Auricchio heads a large team that tested whether a blood protein called S100B can forecast how patients fare after a spontaneous bleed around the brain, usually from a burst aneurysm. Their prospective study followed 108 consecutive patients admitted between January 2022 and August 2024, measuring S100B at one day, three days, and seven days after admission.
Higher early S100B levels went together with worse function and higher death rates, even after other severity measures were taken into account. Machine learning analysis ranked the day-one and day-three values as the strongest predictors of functional outcome. A link with delayed cerebral ischemia, a later complication, appeared in simple analysis but faded once illness severity was included. The authors call S100B a promising early marker while asking for larger studies before it guides care.
Catalog record
| CREATOR | Anna Maria Auricchio, Silvia Baroni, Michele Nichelatti, Giulia Napoli, Francesco Calvanese, Giovanni Maria Ceccarelli, Renata Martinelli, Grazia Menna, Marco Obersnel, Luca Scarcia, Andrea Alexandre, Anselmo Caricato |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |