Parthenolide accelerates diabetic wound healing through the STAT3 and TNF-α/NF-kappaB pathways
Dan Song, Zhuo Zeng, Hui Tang, Kaiqi Chen, JiaMin Li, Yi Liang, Xia Lei, Hong Liu · 2026
Read Parthenolide accelerates diabetic wound healing through the STAT3 and TNF-α/NF-kappaB pathways by Dan Song, Zhuo Zeng, Hui Tang, Kaiqi Chen, JiaMin Li, Yi Liang, Xia Lei, Hong Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13593657.txt.
Description
Dan Song and colleagues investigated parthenolide, a natural compound from the feverfew plant, as a treatment to speed healing of diabetic wounds. Their 2026 study combined computer-based target prediction with experiments in diabetic mice and in cultured macrophages, the immune cells that shape inflammation at a wound.
The prediction pointed to two signaling hubs, TNF-α and STAT3, as likely targets. In mice, the two higher doses clearly sped wound closure while the lowest dose gave no stable benefit. Tissue staining showed more skin cell growth, more new blood vessels, and more macrophages switched to the calming M2 type. Cell experiments supported the idea that parthenolide works by tuning those two pathways and nudging macrophages toward their healing form, making it a candidate worth further testing for stubborn diabetic wounds.
Catalog record
| CREATOR | Dan Song, Zhuo Zeng, Hui Tang, Kaiqi Chen, JiaMin Li, Yi Liang, Xia Lei, Hong Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45744 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |