High prevalence of colistin heteroresistance in Pseudomonas aeruginosa bloodstream isolates and associated clinical factors
Ekin Kırbaş, Muhammed Cihan Işık, Rashad Ismayilov, Serhat Ünal, Banu Sancak · 2026
Read High prevalence of colistin heteroresistance in Pseudomonas aeruginosa bloodstream isolates and associated clinical factors by Ekin Kırbaş, Muhammed Cihan Işık, Rashad Ismayilov, Serhat Ünal, Banu Sancak (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13593643.txt.
Description
Ekin Kırbaş and colleagues measured how often hidden colistin resistance lurks in Pseudomonas aeruginosa bacteria taken from bloodstream infections. Colistin is a last-resort antibiotic for strains that resist carbapenems, and heteroresistance means a small resistant minority hides inside a population that routine testing calls susceptible. Their 2026 study examined seventy such bloodstream isolates.
Using the reference population analysis method, they found heteroresistance in about six of every ten isolates, a strikingly high share. A simpler gradient test missed every single one of those strains. Being sixty or older, having no recent hospital stay, and a particular colistin test value were each linked to higher risk. Hidden resistance did not, however, track with deaths at thirty or ninety days, and the authors say its real clinical weight still needs to be worked out.
Catalog record
| CREATOR | Ekin Kırbaş, Muhammed Cihan Işık, Rashad Ismayilov, Serhat Ünal, Banu Sancak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39704 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |