JAG1 c.1615C > T mutation impairs bile duct regeneration but not differentiation in hepatic organoids derived from a patient with Alagille syndrome
Zirui Wan, Haiyan Zhang, Lu Zhang, Xiaofang Cao, Lisha An, Bin Wang, Jingyun Guan, Jinlin Jia, Chen Liu, Xiaohua Jin, Yue Li, Guohua Liu, Xu Ma · 2026
Read JAG1 c.1615C > T mutation impairs bile duct regeneration but not differentiation in hepatic organoids derived from a patient with Alagille syndrome by Zirui Wan, Haiyan Zhang, Lu Zhang, Xiaofang Cao, Lisha An, Bin Wang, Jingyun Guan, Jinlin Jia, Chen Liu, Xiaohua Jin, Yue Li, Guohua Liu, Xu Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13593616.txt.
Description
Alagille syndrome is an inherited condition in which the liver forms too few bile ducts. Most cases trace to faults in a gene called JAG1. Zirui Wan and co-authors grew liver organoids, lab grown versions of the tissue, from cells carrying one such fault, a single letter change in JAG1. Using base editors, they fixed the fault in patient cells and introduced it into healthy cells, making matched pairs that differ only at that letter. They then watched how the organoids grew.
To their surprise, the mutant organoids made bile duct cells just as well as the healthy ones. The real differences lay elsewhere: mutant cells survived less well, responded weakly to a growth signal, and lost their internal polarity. The authors argue that the missing ducts in this disease may stem from failed regeneration rather than failed formation, a shift that points therapy research in a new direction.
Catalog record
| CREATOR | Zirui Wan, Haiyan Zhang, Lu Zhang, Xiaofang Cao, Lisha An, Bin Wang, Jingyun Guan, Jinlin Jia, Chen Liu, Xiaohua Jin, Yue Li, Guohua Liu, Xu Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |