Kidney organoids as a platform to study plasminogen-induced injury and uPA-based therapies
Marina de Cos, Samuel Mon-Wei Yu, Jacob Wright, Nanditha Anandakrishnan, Kristin Meliambro, Jenny S Wong, Evren Azeloglu, Kirk N Campbell · 2026
Read Kidney organoids as a platform to study plasminogen-induced injury and uPA-based therapies by Marina de Cos, Samuel Mon-Wei Yu, Jacob Wright, Nanditha Anandakrishnan, Kristin Meliambro, Jenny S Wong, Evren Azeloglu, Kirk N Campbell (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13593615.txt.
Description
Marina de Cos and co-authors use, in 2026, lab-grown kidney organoids to study how a urine protein damages the kidney. Plasminogen leaking into urine is blamed in protein-losing kidney diseases, but animal models translate poorly. Organoids grown from human stem cells offer a closer stand-in for the human nephron.
Exposed organoids showed injury in the filtering units, with key podocyte markers falling and cell death rising, and damage in the first tubule segment while later segments were spared. A drug that blocks the protein's activator partly restored the markers but did not stop cell death. The authors offer the organoid system as a testing platform for such therapies.
Catalog record
| CREATOR | Marina de Cos, Samuel Mon-Wei Yu, Jacob Wright, Nanditha Anandakrishnan, Kristin Meliambro, Jenny S Wong, Evren Azeloglu, Kirk N Campbell |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |