Allostatic load as a framework for understanding early-onset colorectal cancer: current biomarker evidence and future directions
Efosa Enoma, Atuahene Adu-Gyamfi, Jianna Carter, Sarah Wu, Barbara Nemesure, Jennie L. Williams · 2026
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Description
Efosa Enoma, Atuahene Adu-Gyamfi, Jianna Carter, Sarah Wu, Barbara Nemesure, and Jennie Williams published a 2026 review asking whether lifelong stress wear helps explain colon cancer striking ever younger adults. Overall colorectal cancer has fallen for fifty years thanks to screening. Yet cases under age fifty have risen since the mid nineteen nineties, defying the trend.
The authors frame the puzzle through allostatic load, the body's cumulative burden from chronic stress, measured by panels of biomarkers. They searched two databases for cohort and case control studies linking that burden to early onset disease. Twelve studies qualified. Only three had measured allostatic load directly with its metabolic and cardiovascular markers. The review maps what the biomarker evidence shows so far and where future studies must go.
Catalog record
| CREATOR | Efosa Enoma, Atuahene Adu-Gyamfi, Jianna Carter, Sarah Wu, Barbara Nemesure, Jennie L. Williams |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |