Sex-based differences in the gut-metabolism axis in aging and Nrf2-deficient mice
Si Yang, Jiayi Zhou, Yuhan Yang, Pei Xu, Bolan Yu, Rami Salim Najjar · 2026
Read Sex-based differences in the gut-metabolism axis in aging and Nrf2-deficient mice by Si Yang, Jiayi Zhou, Yuhan Yang, Pei Xu, Bolan Yu, Rami Salim Najjar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13592584.txt.
Description
Si Yang and five colleagues compare gut microbes and metabolism in aging mice, split by sex and by whether a protective gene, Nrf2, was missing. Nrf2 guards cells against oxidative damage and also steers fat and sugar handling. Young and old mice of both types took glucose tests, blood fat checks, and hormone measures, while gut bacteria were read from droppings and liver and fat tissue were examined.
Aging male mice lacking Nrf2 handled glucose worst, and fat piled into liver and body fat in old mice of both sexes and gene types. Blood fat patterns split by sex and gene in divergent ways. Female knockout mice showed notably thinner gut microbe diversity. Yang and the team conclude sex shapes how aging rewires the gut metabolism axis.
Catalog record
| CREATOR | Si Yang, Jiayi Zhou, Yuhan Yang, Pei Xu, Bolan Yu, Rami Salim Najjar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |