Neurodegeneration as a dysregulation of neuroimmune crosstalk
F. Chris Bennett, Soyon Hong, Ning Jiang, Ivan Marazzi · 2026
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Description
Bennett and colleagues argued that brain-wasting diseases should be understood as a breakdown of talk between the nervous and immune systems, in a 2026 essay. Studies now show immune cells stationed at the brain's borders and entering the tissue, acting as guards that shape nerve-cell strength and repair.
Bennett groups the field into lenses: outside-in signals, in which adaptive immune responses from the rest of the body engage the brain. Inside-out circuits are those in which the brain's cells direct communication. And gene-regulatory programs lock immune states in. Faulty immunity is cast as a cause alongside nerve-cell fragility, not a side effect. The authors point to the Alzheimer's antibodies as evidence that tuning this dialogue can change a disease. They call for treatments that restore immune balance or reset the epigenetic switches, chemical marks that hold cell states and guide behavior.
Catalog record
| CREATOR | F. Chris Bennett, Soyon Hong, Ning Jiang, Ivan Marazzi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |