SUDEP and mortality in developmental and epileptic encephalopathies: A meta‐analysis of randomized clinical trials and extension studies
Pierludovico Moro, Maria Sole Borioni, Adolfo Mazzeo, Enrico Cocchi, Carlo Di Bonaventura, Emanuele Cerulli Irelli · 2026
Read SUDEP and mortality in developmental and epileptic encephalopathies: A meta‐analysis of randomized clinical trials and extension studies by Pierludovico Moro, Maria Sole Borioni, Adolfo Mazzeo, Enrico Cocchi, Carlo Di Bonaventura, Emanuele Cerulli Irelli (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13592499.txt.
Description
Pierludovico Moro and five colleagues pool, in 2026, trial data to estimate death and sudden unexpected death in severe developmental epilepsies. These syndromes pair stubborn seizures with developmental harm and carry high early death risk, yet counts by syndrome were thin. Their Bayesian pooling covered 37 trials and 15 extension studies with 3,757 patients, most with Lennox-Gastaut or Dravet syndrome.
Thirty seven deaths occurred, about half classed as sudden unexpected death in epilepsy. The pooled sudden death rate sat near four per thousand patient years, highest in Dravet syndrome at over seven. Overall death ran near nine per thousand patient years. Moro and the team caution that trial groups likely undercount real world rates, and urge population studies.
Catalog record
| CREATOR | Pierludovico Moro, Maria Sole Borioni, Adolfo Mazzeo, Enrico Cocchi, Carlo Di Bonaventura, Emanuele Cerulli Irelli |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52152 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |