Induction and Stabilization of Peptide Alpha‐Helices on Silica Nanoparticles
Fidel Lozano‐Elena, Seyed Amirabbas Nazemi, Patrick Shahgaldian, Sebastian Wendeborn · 2026
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Description
Fidel Lozano-Elena and three colleagues pin, in 2026, short protein chains onto silica beads in a way that locks them into helix shapes. Helices steer how proteins grip partners, yet lone peptides flop loose and lose the shape, above all when heated. Their method uses a changeable covalent link that lets attached peptides settle into their lowest energy form. Alanine rich chains dotted with lysine anchors were the test case.
Attachment point mattered: end on links sparked helices, while links spaced every second turn gave the best heat endurance. One face of each helix still points outward, free to bind. A streptavidin binding peptide kept its grip after mounting and shrugged off heat far better than free copies, the team shows.
Catalog record
| CREATOR | Fidel Lozano‐Elena, Seyed Amirabbas Nazemi, Patrick Shahgaldian, Sebastian Wendeborn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29926 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |