Generation of two iPSC lines from ALS patients harboring C9orf72 hexanucleotide repeat expansions
Dide Wu, Ana Kojic, Jay P Ross, Dong Li, Parker Walther, Neelam Goyal, Jacinda Sampson, Joseph C Wu · 2026
Read Generation of two iPSC lines from ALS patients harboring C9orf72 hexanucleotide repeat expansions by Dide Wu, Ana Kojic, Jay P Ross, Dong Li, Parker Walther, Neelam Goyal, Jacinda Sampson, Joseph C Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13592274.txt.
Description
Dide Wu and co-authors create two stem cell lines from patients with ALS, in a 2026 paper. ALS is a fatal disease that kills the nerve cells controlling movement. The most common genetic driver is a repeated stretch of DNA in a gene called C9orf72. Both donors carried that repeat expansion. The team reprogrammed their cells into induced pluripotent stem cells, which can become many cell types.
Checks confirmed the new lines act like true stem cells. They showed the standard marker proteins, held normal chromosome sets, and could form all three early tissue layers. Those tests mark the lines as sound research material. The authors say the lines give labs a platform to model ALS in a dish. Work with them can probe how the repeat expansion drives the disease.
Catalog record
| CREATOR | Dide Wu, Ana Kojic, Jay P Ross, Dong Li, Parker Walther, Neelam Goyal, Jacinda Sampson, Joseph C Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |