Circuit-specific remodeling of synaptic co-transmission in stress-responsive networks
Hoyong Park, Hyogyun Kim, Minsung Sim, Doyeon Ham, ChiHye Chung · 2026
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Description
Neurons mostly speak with one chemical messenger, but some use two or more. Hoyong Park and co-authors review this co-transmission in stress circuits. Extra messengers let a synapse mix excitation, inhibition, and modulation in one contact. Stress reshapes that mix in specific circuits. The lateral habenula, monoamine nuclei, and hippocampus each show their own pattern of change. Balance between transmitters shifts rather than any single system acting alone.
The review gathers mechanisms that might recalibrate the signaling. It frames co-transmission as a moving substrate of stress plasticity. Both healthy adaptation and disorders like depression may ride on it. The authors point to new treatment angles for mood disorders.
Catalog record
| CREATOR | Hoyong Park, Hyogyun Kim, Minsung Sim, Doyeon Ham, ChiHye Chung |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |