From force to fate: Implications of mechanomemory in lung disease
Natalia Campo-Ortiz de Zárate, Sara M Exojo-Ramírez, Guillermo M Albaiceta, Manuel Chacón · 2026
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Description
Natalia Campo-Ortiz de Zárate and three colleagues review, in 2026, a fresh idea in lung biology: cells may remember past mechanical force. Lung tissue is soft, yet disease can stiffen it many times over. Cells sense that stiffness and change their gene activity, shape, and inner wiring. The review asks whether those changes persist after the force fades, locking cells into a sick state.
Such mechanomemory could explain why lung scarring feeds on itself and why tumors resist drugs, the authors argue. Stored signals in cell skeletons and gene tags may keep scar making cells active long past the first injury. Campo-Ortiz de Zárate and the team propose that erasing this memory could break the cycle, and they map the open questions for the field.
Catalog record
| CREATOR | Natalia Campo-Ortiz de Zárate, Sara M Exojo-Ramírez, Guillermo M Albaiceta, Manuel Chacón |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61843 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |