Identification and prognostic analysis of genes related to CTNNB1 mutations in hepatocellular carcinoma
Ningqi Zhu, Guo Zhang, Xiaotian Shen, Zule Chen, Ying Li, Diyu Chen, Huliang Jia · 2026
Read Identification and prognostic analysis of genes related to CTNNB1 mutations in hepatocellular carcinoma by Ningqi Zhu, Guo Zhang, Xiaotian Shen, Zule Chen, Ying Li, Diyu Chen, Huliang Jia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13591878.txt.
Description
Ningqi Zhu and six colleagues hunt, in 2026, the genes switched on by a mutant driver of liver cancer. The driver, CTNNB1, locks a growth pathway in the on position in roughly a third of these cancers. The team built mouse liver tumors with the mutant gene, read their gene activity, and merged the results with human tumor data from two large banks. Machine learning distilled a signature of 15 genes.
That signature guessed mutation status with high accuracy in both human datasets. One gene, MT3, stood out: high levels marked worse survival in public data and in the team's own tissue set. Zhu and colleagues offer MT3 as a fresh warning marker and the signature as a sorting tool for liver cancer care.
Catalog record
| CREATOR | Ningqi Zhu, Guo Zhang, Xiaotian Shen, Zule Chen, Ying Li, Diyu Chen, Huliang Jia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42435 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |