The rate and spectrum of germline mutations in chicken from a commercial pedigree line
Eugenio López-Cortegano, Bolívar Samuel Sosa-Madrid, Andreas Kranis · 2026
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Description
Eugenio López-Cortegano and two colleagues measure fresh mutations in chickens from a commercial breeding line. New germline mutations, passed from parent to chick, supply the raw variation breeders and evolution both work with. The team sequenced full genomes from 194 parent chick trios. That design lets each new change be spotted against both parents and counted directly.
They peg the rate at about three and a half mutations per billion DNA letters per generation. Fathers supplied roughly twice as many new mutations as mothers. Tiny chromosomes mutated a bit faster than large ones. Genes differed widely in how prone they are to harmful change, with immunity and development genes near the top. The team offers the ranking to guide breeding choices.
Catalog record
| CREATOR | Eugenio López-Cortegano, Bolívar Samuel Sosa-Madrid, Andreas Kranis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |