Decoding the association between platinum resistance and HPV status in cervical cancer using organoid models
Bin Zhang, Yao Lin, Suyao Xie, Xiaohong Zhu, Xinping Zhang, Lingyu Hu, Min Qiu, Hongkai Lee, Chongyang Shen, Mingliang You, Huayang Xing · 2026
Read Decoding the association between platinum resistance and HPV status in cervical cancer using organoid models by Bin Zhang, Yao Lin, Suyao Xie, Xiaohong Zhu, Xinping Zhang, Lingyu Hu, Min Qiu, Hongkai Lee, Chongyang Shen, Mingliang You, Huayang Xing (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13591797.txt.
Description
Bin Zhang leads a 2026 study using lab grown tumor clusters to probe why some cervical cancers resist platinum drugs. Cervical cancer is driven largely by high risk HPV strains, and platinum drugs anchor care when it returns or spreads. The team grew 37 organoids, mini tumors that keep the traits of the source cancer, and tested drug response in 27 of them.
Clusters carrying high risk HPV types other than type 16 resisted platinum drugs more than HPV free ones, the team found. Resistant clusters repaired DNA faster, ran a growth pathway hard, and dodged cell death signals. A drug blocking that pathway restored platinum power in the HPV positive group only. Zhang and colleagues see a path to tailored add on care.
Catalog record
| CREATOR | Bin Zhang, Yao Lin, Suyao Xie, Xiaohong Zhu, Xinping Zhang, Lingyu Hu, Min Qiu, Hongkai Lee, Chongyang Shen, Mingliang You, Huayang Xing |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47386 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |