Structural and molecular determinants of medial temporal lobe network vulnerability in aging and Alzheimer’s disease
Elise Saul, Léa Chauveau, Brigitte Landeau, Jade Lasserve, Blandine Montagne, Emilie Foyard, Géraldine Poisnel, Gaël Chételat, Robin de Flores · 2026
Read Structural and molecular determinants of medial temporal lobe network vulnerability in aging and Alzheimer’s disease by Elise Saul, Léa Chauveau, Brigitte Landeau, Jade Lasserve, Blandine Montagne, Emilie Foyard, Géraldine Poisnel, Gaël Chételat, Robin de Flores (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13591752.txt.
Description
Elise Saul and eight colleagues map, in 2026, why two memory networks in the inner temporal lobe wear down early in Alzheimer's disease. The study drew on 88 healthy older adults from a French cohort. Brain scans traced the wiring of both networks, a PET scan measured amyloid buildup, and blood tests gauged star shaped support cell activity, a sign of brain swelling.
Each network leaned on partly distinct wiring bundles, the team found. Amyloid's link to wiring health bent in a curve, rising then falling across early stages. For the rear network, high support cell activity made amyloid's harm worse. In the front network, stronger signaling paired with weaker wiring when amyloid ran high, hinting at a strained workaround.
Catalog record
| CREATOR | Elise Saul, Léa Chauveau, Brigitte Landeau, Jade Lasserve, Blandine Montagne, Emilie Foyard, Géraldine Poisnel, Gaël Chételat, Robin de Flores |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68638 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |