Exercise timing as a potential temporal regulator of neurolymphatic physiology in neurodegenerative proteinopathies: a mechanistic framework
Chaowen Hou, Yuxin Gao, Hongyu Wang · 2026
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Description
Chaowen Hou, Yuxin Gao, and Hongyu Wang argue that when people exercise may matter for brain disease, not just how much. Studies of exercise and brain decline mostly track dose: how long, how hard, and step counts. The review treats exercise timing itself as a factor that works through protein clearance, blood vessel pulsing, daily body rhythms, and sleep structure.
Morning exercise may act mainly by setting the body clock. Afternoon exercise may act through vessel and metabolic effects. Gentle evening activity may act through sleep. The focus is Alzheimer's and Parkinson's disease, where misfolded proteins spread over time. The authors stress that proof in humans is still indirect. They call for trials that match dose and track activity, sleep, and biomarkers together.
Catalog record
| CREATOR | Chaowen Hou, Yuxin Gao, Hongyu Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 141 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |