Non-Malignant T Cells as Determinants of Immunotherapeutic Response in Chronic Lymphocytic Leukemia: Towards Personalized Strategies
Agata Kosmaczewska, Lidia Ciszak · 2026
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Description
Agata Kosmaczewska and Lidia Ciszak review the double life of healthy T cells in chronic lymphocytic leukemia. The cancer grows from B cells, but the T cells around them steer its course. They fight the tumor yet also send signals that help new cancer subclones arise. Every modern therapy touches them somehow.
Kinase blockers, degraders, cell death drugs, T cell engagers, checkpoint drugs, and cell therapy all reshape the T cell pool. Knowing that pool's state could help match patients to treatments with the best benefit to risk balance. The review maps T cell changes across the disease and argues for personalized immunotherapy plans.
Catalog record
| CREATOR | Agata Kosmaczewska, Lidia Ciszak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |