OTUD7B Activates the Caspase-8-RIPK1-NEMO Complex-Regulated NF-κB Pathway to Promote Triple-Negative Breast Cancer Metastasis
Fiona Tsui-Fen Cheng, Kung-Ju Chen, Jing-Quan Zheng, Hui-Wen Chiu, Hui-Yu Lin, Yuan-Feng Lin · 2026
Read OTUD7B Activates the Caspase-8-RIPK1-NEMO Complex-Regulated NF-κB Pathway to Promote Triple-Negative Breast Cancer Metastasis by Fiona Tsui-Fen Cheng, Kung-Ju Chen, Jing-Quan Zheng, Hui-Wen Chiu, Hui-Yu Lin, Yuan-Feng Lin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13591338.txt.
Description
Fiona Tsui-Fen Cheng and five co-authors identify an enzyme that helps the most aggressive breast cancer spread, in a 2026 study. Triple-negative breast cancer often seeds the lungs and brain, and its drivers are poorly mapped. The enzyme, OTUD7B, removes ubiquitin tags from proteins, sparing them from destruction.
Database analysis of 424 patients showed the enzyme is strongly overproduced in these tumors and tracks with worse metastasis-free survival. Removing it crippled cancer cell migration and lung colony formation; adding it boosted both, and only when its tag-removing activity worked. The mechanism runs through a signaling complex: the enzyme stabilizes a partner protein, keeping the NF-kappa-B pathway switched on. Depleting it tripled a death enzyme's activity and pushed cells into a fiery death program. Blocking the pathway cut enzyme-driven migration by up to ninety percent.
Catalog record
| CREATOR | Fiona Tsui-Fen Cheng, Kung-Ju Chen, Jing-Quan Zheng, Hui-Wen Chiu, Hui-Yu Lin, Yuan-Feng Lin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |