Promoter Hypermethylation-Driven NPHS2 Silencing Promotes Immune Escape and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma
Shangjian Li, Qipeng Han, Xinying Sun, Rongrong Yu · 2026
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Description
Shangjian Li, Qipeng Han, Xinying Sun, and Rongrong Yu study a silenced gene in kidney cancer in this 2026 paper. The cancer is a common form in the urinary system. Using a public data set, the team picked a gene whose control region is heavily marked by a chemical tag that switches genes off.
Tests on patient tissue confirmed the heavy tagging, and a drug that removes such tags raised the gene's protein in cancer cells. Raising the gene in lab cells curbed growth, movement, and shape change linked to spread. In drug-resistant cells and in mice with tumors, the gene also tied into immune escape and loss of response to a key drug.
Catalog record
| CREATOR | Shangjian Li, Qipeng Han, Xinying Sun, Rongrong Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |