Gastric Cancer-Derived Exosomes Activate Mast Cells via the SCF/c-KIT Pathway to Drive Angiogenesis and Metastasis
Shaoxiong Bai, Yilei Duan, Tian Yao, Yanan Shi, Xin Zhang, Xiaole Ma, Kai Jia · 2026
Read Gastric Cancer-Derived Exosomes Activate Mast Cells via the SCF/c-KIT Pathway to Drive Angiogenesis and Metastasis by Shaoxiong Bai, Yilei Duan, Tian Yao, Yanan Shi, Xin Zhang, Xiaole Ma, Kai Jia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13591335.txt.
Description
Stomach tumours shed tiny sacs that carry notes to other cells, and those notes can help the tumour grow new blood paths and spread. Shaoxiong Bai and co-authors trace one such note in a 2026 study. The sacs from stomach tumour cells, but not from sound stomach cells, ran rich in a growth signal.
That signal woke mast cells, which drifted in, burst their stores, and freed a cutter enzyme. The enzyme switched on a growth path in blood path cells and raised a vessel growth factor. In mice, tumour sacs sped spread to the lungs and new vessel growth. A drug that blocks the signal's dock cut both. The team marks the sac to mast cell chain as a drug target.
Catalog record
| CREATOR | Shaoxiong Bai, Yilei Duan, Tian Yao, Yanan Shi, Xin Zhang, Xiaole Ma, Kai Jia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |