Cholesterol Metabolism in Cancer Patients: Mechanisms, Treatment-Related Effects, and Cardio-Oncology Management
Mariagrazia Piscione, Barbara Pala, Francesco Cribari, Paola Gualtieri, Dario Gaudio, Marco Alfonso Perrone, Laura Di Renzo · 2026
Read Cholesterol Metabolism in Cancer Patients: Mechanisms, Treatment-Related Effects, and Cardio-Oncology Management by Mariagrazia Piscione, Barbara Pala, Francesco Cribari, Paola Gualtieri, Dario Gaudio, Marco Alfonso Perrone, Laura Di Renzo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13591320.txt.
Description
Mariagrazia Piscione and six co-authors review how cholesterol handling links cancer and heart disease. Tumors gorge on cholesterol to build membranes and feed growth signals, and they twist the body's fat balance in the process. Studies tying blood cholesterol to cancer risk disagree, partly because tumors differ and because illness itself lowers cholesterol, muddying cause and effect. The review walks through the cell biology, from uptake and synthesis to effects on inflammation, blood vessel growth, and immune escape.
Cancer treatments then disturb fat levels further, speeding artery disease in survivors. Cholesterol-lowering drugs, above all statins, already protect the heart in this setting and may also slow tumors by choking a key production pathway. Newer agents add options and may pair well with immune therapy. The authors map the two-way traffic for cardio-oncology care.
Catalog record
| CREATOR | Mariagrazia Piscione, Barbara Pala, Francesco Cribari, Paola Gualtieri, Dario Gaudio, Marco Alfonso Perrone, Laura Di Renzo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |