Novel biofilm-targeted therapeutics for oral infections: enzymes, EPS disruptors, phage/CRISPR, photodynamic and cold-plasma approaches — a systematic review
Prabhu Manickam Natarajan, Vijay Ebenezer, Sudhir Rama Varma, Pradeepa Ganesh · 2026
Read Novel biofilm-targeted therapeutics for oral infections: enzymes, EPS disruptors, phage/CRISPR, photodynamic and cold-plasma approaches — a systematic review by Prabhu Manickam Natarajan, Vijay Ebenezer, Sudhir Rama Varma, Pradeepa Ganesh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13591305.txt.
Description
Prabhu Manickam Natarajan and colleagues published a 2026 review of new ways to attack the slimy bacterial communities, called biofilms, behind stubborn mouth infections. Biofilms shield bacteria from antibiotics and cleaning, which is why gum and tooth infections return so often. The review covers five non-antibiotic strategies that each strike a different weakness in the biofilm's defenses.
The strategies include enzymes that digest the slime, chemicals that break it apart, viruses and gene tools that kill bacteria, light-activated treatment, and cold plasma. The team graded study quality across laboratory, animal, and clinical work, mapping which approaches are ready for patients and which remain experimental.
Catalog record
| CREATOR | Prabhu Manickam Natarajan, Vijay Ebenezer, Sudhir Rama Varma, Pradeepa Ganesh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |