CNTN5 Promotes Invasion and Metastasis in Non‐Small Cell Lung Cancer by Regulating YAP1 Nuclear Translocation
Jiarui Wang, Mengtao Wang, Yanze Yin, Ao Zeng, Keyi Chen, Zhilong Xu, Jie Dai · 2026
Read CNTN5 Promotes Invasion and Metastasis in Non‐Small Cell Lung Cancer by Regulating YAP1 Nuclear Translocation by Jiarui Wang, Mengtao Wang, Yanze Yin, Ao Zeng, Keyi Chen, Zhilong Xu, Jie Dai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13591293.txt.
Description
Jiarui Wang and six co-authors trace how a membrane protein helps the most common lung cancer spread, in this 2026 study. The protein is contactin-5, or CNTN5, and non-small cell lung cancer owes much of its deadliness to metastasis. The team measured the protein in tumor samples and tested what raising or lowering it does to cancer cells.
Tumors carried more CNTN5 than normal tissue, and patients with more of it fared worse. Boosting the protein made cancer cells migrate and invade faster and helped them colonize lungs in mice, while silencing it slowed them. The mechanism ran through the Hippo signaling pathway: CNTN5 raised levels of the effector YAP1 and pushed it into the nucleus, switching on growth programs, and silencing YAP1 partly undid the effect. Tests also supported a partnership between CNTN5 and a second protein, PTPN13. The authors propose CNTN5 as a marker and drug target.
Catalog record
| CREATOR | Jiarui Wang, Mengtao Wang, Yanze Yin, Ao Zeng, Keyi Chen, Zhilong Xu, Jie Dai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |