Connective tissue and genetics in the pathogenesis of rectal prolapse: A scoping review
Matthew Davenport, Alexander O'Connor, William G Newman, Andrew P Morris, Abhiram Sharma, Gemma Faulkner, Dipesh H Vasant, John McLaughlin, Edward Kiff, Karen Telford · 2026
Read Connective tissue and genetics in the pathogenesis of rectal prolapse: A scoping review by Matthew Davenport, Alexander O'Connor, William G Newman, Andrew P Morris, Abhiram Sharma, Gemma Faulkner, Dipesh H Vasant, John McLaughlin, Edward Kiff, Karen Telford (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13591292.txt.
Description
Matthew Davenport and nine co-authors review genetics in rectal prolapse in a 2026 paper. The rectum can slip out even without the classic risk factors of straining, childbirth injury, or age. Inherited connective tissue diseases show up often in such patients. Their review asks whether tissue genes drive the disease.
Sixty studies passed screening from over four thousand candidates. Prolapse proved common in Ehlers-Danlos and Marfan syndromes. Joint hypermobility tracked with earlier onset and recurrence after surgery. Tissue studies found disordered collagen and elastin in the pelvic floor. Muscle forming cell density was reduced as well. Heritability patterns remain poorly studied, the team finds. Genetic testing evidence is thin but growing. The review charts what a tissue based account of prolapse still needs.
Catalog record
| CREATOR | Matthew Davenport, Alexander O'Connor, William G Newman, Andrew P Morris, Abhiram Sharma, Gemma Faulkner, Dipesh H Vasant, John McLaughlin, Edward Kiff, Karen Telford |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |