Radiation resistance is a property of long-lived plasma cells but not their precursors
Rosela H Webster, Alexandra R Dvorscek, Zhoujie Ding, David M Tarlinton, Marcus J Robinson · 2026
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Description
Rosela H Webster and four colleagues ask, in 2026, whether long lived plasma cells shrug off radiation that kills their parent cells. Plasma cells make antibodies and can persist for decades, guarding old immunity. The team irradiated mice, rebuilt their blood systems with marked donor marrow, and tracked whose plasma cells remained weeks later. A second setup used mice whose plasma cells carry time stamps.
Counts bounced back within four weeks, yet a solid share of plasma cells still came from the irradiated host at eight weeks. Many were newly made by host B cells that had survived. When donor B cells were scarce, host cells made even more. Webster and the team read this as proof of a hardy, long lived pool plus rivalry for space.
Catalog record
| CREATOR | Rosela H Webster, Alexandra R Dvorscek, Zhoujie Ding, David M Tarlinton, Marcus J Robinson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34910 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |