KDM2B controls HIF levels and activity through its JmjC and CxxC domains
Michael Batie, Dilem Shakir, Chun-Sui Kwok, Gemma Bell, Jiahua Kou, Ali Bakhsh, Sonia Rocha · 2026
Read KDM2B controls HIF levels and activity through its JmjC and CxxC domains by Michael Batie, Dilem Shakir, Chun-Sui Kwok, Gemma Bell, Jiahua Kou, Ali Bakhsh, Sonia Rocha (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13591259.txt.
Description
Michael Batie and six colleagues study KDM2B, a gene editing enzyme, and its grip on the cell's answer to low oxygen. Cells sense low oxygen through HIF proteins, which switch on survival genes. KDM2B itself is switched on by HIF, hinting at a loop. Working across several cell lines, the team cut or raised KDM2B and watched what HIF did in reply.
Effects split by cell type: cutting KDM2B weakened HIF in bone and breast cancer cells yet strengthened it in cervical cells. Where it weakened, HIF protein, its gene message, and its grip on target genes all fell. Two parts of KDM2B proved vital, its chemical editing core and its DNA binding tip. Batie and the team also found KDM2B helps recruit the gene reading machine, and that cells need it to grow under low oxygen.
Catalog record
| CREATOR | Michael Batie, Dilem Shakir, Chun-Sui Kwok, Gemma Bell, Jiahua Kou, Ali Bakhsh, Sonia Rocha |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |