ACT001 suppresses ox-LDL-mediated macrophage ferroptosis via activating the NRF2 pathway: An in vitro mechanistic study relevant to atherosclerosis
Yangyang Tao, Yuwu Chen, Yonghou Zhao, Jianbo Cai · 2026
Read ACT001 suppresses ox-LDL-mediated macrophage ferroptosis via activating the NRF2 pathway: An in vitro mechanistic study relevant to atherosclerosis by Yangyang Tao, Yuwu Chen, Yonghou Zhao, Jianbo Cai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13591240.txt.
Description
Yangyang Tao and co-authors test, in a 2026 cell study, whether a new anti-inflammatory compound can stop a form of cell death that feeds artery disease. Oxidized cholesterol pushes macrophages, the artery wall's cleanup cells, into ferroptosis, an iron-driven death that worsens plaques.
Mouse macrophages were poisoned with oxidized cholesterol, then rescued with the compound ACT001. Marker panels tracked fat peroxidation, iron load, energy organelle health, and rust-like damage products. The compound switched on the NRF2 defense pathway, whose master switch moves into the nucleus to raise protective genes. Blocking that death route could one day steady plaques.
Catalog record
| CREATOR | Yangyang Tao, Yuwu Chen, Yonghou Zhao, Jianbo Cai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |